Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30800
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dc.contributor.authorMicol-Ponce, Rosa-
dc.contributor.authorSarmiento, Raquel-
dc.contributor.authorFontcuberta-Cervera, Sara-
dc.contributor.authorCabezas-Fuster, Adrián -
dc.contributor.authorde Bures, Anne-
dc.contributor.authorSáez-Vásquez, Julio-
dc.contributor.authorPonce, María Rosa-
dc.contributor.otherDepartamentos de la UMH::Biología Aplicadaes_ES
dc.date.accessioned2024-01-26T22:31:52Z-
dc.date.available2024-01-26T22:31:52Z-
dc.date.created2020-12-
dc.identifier.citationPlant Physiology , December 2020, Vol. 184, pp. 2022–2039es_ES
dc.identifier.issn1532-2548-
dc.identifier.issn0032-0889-
dc.identifier.urihttps://hdl.handle.net/11000/30800-
dc.description.abstractRibosome biogenesis is crucial for cellular metabolism and has important implications for disease and aging. Human (Homo sapiens) glioma tumor-suppressor candidate region gene2 (GLTSCR2) and yeast (Saccharomyces cerevisiae) Nucleolar protein53 (Nop53) are orthologous proteins with demonstrated roles as ribosome biogenesis factors; knockdown of GLTSCR2 impairs maturation of 18S and 5.8S ribosomal RNAs (rRNAs), and Nop53 is required for maturation of 5.8S and 25S rRNAs. Here, we characterized SMALL ORGAN4 (SMO4), the most likely ortholog of human GLTSCR2 and yeast Nop53 in Arabidopsis (Arabidopsis thaliana). Loss of function of SMO4 results in a mild morphological phenotype; however, we found that smo4 mutants exhibit strong cytological and molecular phenotypes: nucleolar hypertrophy and disorganization, overaccumulation of 5.8S and 18S rRNA precursors, and an imbalanced 40S:60S ribosome subunit ratio. Like yeast Nop53 and human GLTSCR2, Arabidopsis SMO4 participates in 5.8S rRNA maturation. In yeast, Nop53 cooperates with mRNA transport4 (Mtr4) for 5.8S rRNA maturation. In Arabidopsis, we found that SMO4 plays similar roles in the 5.8S rRNA maturation pathway than those described for MTR4. However, SMO4 seems not to participate in the degradation of by-products derived from the 5′-external transcribed spacer (ETS) of 45S pre-rRNA, as MTR4 does.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent18es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationGenéticaes_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes_ES
dc.titleSMALL ORGAN4 Is a Ribosome Biogenesis Factor Involved in 5.8S Ribosomal RNA Maturationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1104/pp.19.01540es_ES
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Artículos Biología Aplicada


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