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dc.contributor.authorRubio-Camacho, Marta-
dc.contributor.authorAlacid Martínez, Yolanda Inmaculada-
dc.contributor.authorMallavia, Ricardo-
dc.contributor.authorMartínez Tomé, María José-
dc.contributor.authorMateo , C. Reyes-
dc.contributor.otherDepartamentos de la UMH::Agroquímica y Medio Ambientees_ES
dc.date.accessioned2024-01-26T10:38:38Z-
dc.date.available2024-01-26T10:38:38Z-
dc.date.created2019-10-15-
dc.identifier.citationNanomaterials 2019, 9(10), 1485es_ES
dc.identifier.issn2079-4991-
dc.identifier.urihttps://hdl.handle.net/11000/30729-
dc.description.abstractMultifunctional nanoparticles have been attracting growing attention in recent years because of their capability to integrate materials with di erent features in one entity, which leads them to be considered as the next generation of nanomedicine. In this work, we have taken advantage of the interesting properties of conjugated polyelectrolytes to develop multicolor fluorescent nanoparticles with integrating imaging and therapeutic functionalities. With this end, thermosensitive liposomes were coated with three recently synthesized polyfluorenes: copoly-((9,9-bis(60-N,N,N-trimethylammonium)hexyl)-2,7-(fluorene)-alt-1,4-(phenylene)) bromide (HTMA-PFP), copoly-((9,9-bis(60-N,N,N-trimethylammonium)hexyl)-2,7-(fluorene)-alt-4,7-(2- (phenyl)benzo(d) (1,2,3) triazole)) bromide (HTMA-PFBT) and copoly-((9,9-bis(60-N,N,Ntrimethylammonium) hexyl)-2,7-(fluorene)-alt-1,4-(naphtho(2,3c)-1,2,5-thiadiazole)) bromide (HTMA-PFNT), in order to obtain blue, green and red fluorescent drug carriers, respectively. The stability, size and morphology of the nanoparticles, as well as their thermotropic behavior and photophysical properties, have been characterized by Dynamic Light Scattering (DLS), Zeta Potential, transmission electron microscope (TEM) analysis and fluorescence spectroscopy. In addition, the suitability of the nanostructures to carry and release their contents when triggered by hyperthermia has been explored by using carboxyfluorescein as a hydrophilic drug model. Finally, preliminary experiments with mammalian cells demonstrate the capability of the nanoparticles to mark and visualize cells with di erent colors, evidencing their potential use for imaging and therapeutic applications.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent18es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmultifunctional fluorescent nanoparticleses_ES
dc.subjectconjugated polyelectrolytes (CPEs)es_ES
dc.subjectthermosensitive liposomes (TSLs)es_ES
dc.subjectbioimaginges_ES
dc.subjectdrug carrieres_ES
dc.subjectrelease experimentses_ES
dc.subject.classificationQuímica Físicaes_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::54 - Químicaes_ES
dc.titlePolyfluorene-Based Multicolor Fluorescent Nanoparticles Activated by Temperature for Bioimaging and Drug Deliveryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/nano9101485es_ES
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