Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30725
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dc.contributor.authorFaria, Melissa-
dc.contributor.authorFuertes, Inmaculada-
dc.contributor.authorPrats, Eva-
dc.contributor.authorAbad, José-Luis-
dc.contributor.authorPadrós, Francesc Xavier-
dc.contributor.authorGómez-Canela, Cristian-
dc.contributor.authorCASAS-SOLIS, JOSEFINA-
dc.contributor.authorJorge, Estévez-
dc.contributor.authorVilanova, Eugenio-
dc.contributor.authorPiña, Benjamín-
dc.contributor.authorRaldúa, Demetrio-
dc.contributor.otherDepartamentos de la UMH::Biología Aplicadaes_ES
dc.date.accessioned2024-01-26T10:35:37Z-
dc.date.available2024-01-26T10:35:37Z-
dc.date.created2018-03-05-
dc.identifier.citationScientific Reports, (2018) 8:4844es_ES
dc.identifier.issn2045-2322-
dc.identifier.urihttps://hdl.handle.net/11000/30725-
dc.description.abstractInhibition and aging of neuropathy target esterase (NTE) by exposure to neuropathic organophosphorus compounds (OPs) can result in OP-induced delayed neuropathy (OPIDN). In the present study we aimed to build a model of OPIDN in adult zebrafish. First, inhibition and aging of zebrafish NTE activity were characterized in the brain by using the prototypic neuropathic compounds cresyl saligenin phosphate (CBDP) and diisopropylphosphorofluoridate (DFP). Our results show that, as in other animal models, zebrafish NTE is inhibited and aged by both neuropathic OPs. Then, a neuropathic concentration inhibiting NTE activity by at least 70% for at least 24 h was selected for each compound to analyze changes in phosphatidylcholines (PCs), lysophosphatidylcholines (LPCs) and glycerolphosphocholine (GPC) profiles. In spite to the strong inhibition of the NTE activity found for both compounds, only a mild increase in the LPCs level was found after 48 h of the exposure to DFP, and no effect were observed by CBDP. Moreover, histopathological evaluation and motor function outcome analyses failed to find any neurological abnormalities in the exposed fish. Thus, our results strongly suggest that zebrafish is not a suitable species for the development of an experimental model of human OPIDN.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent14es_ES
dc.language.isoenges_ES
dc.publisherNature Researches_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationToxicologíaes_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes_ES
dc.titleAnalysis of the neurotoxic effects of neuropathic organophosphorus compounds in adult zebrafishes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-018-22977-4es_ES
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