Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/29212
Full metadata record
DC FieldValueLanguage
dc.contributor.advisorHERRERA, ELOISA-
dc.contributor.authorGonzález Martínez, Rocío-
dc.contributor.otherInstituto de Neurocienciases_ES
dc.date.accessioned2023-04-28T09:15:29Z-
dc.date.available2023-04-28T09:15:29Z-
dc.date.created2022-05-06-
dc.identifier.ismn1735-
dc.identifier.urihttps://hdl.handle.net/11000/29212-
dc.description.abstractRubinstein-Taybi syndrome (RSTS) is a genetic neurodevelopmental disorder characterized by mental impairment and a wide spectrum of congenital abnormalities, that is caused by hemizygous mutations in the KAT3 proteins CBP and P300. The precise function of KAT3 proteins during the development of the central nervous system has not been clearly stated. Here, throughout a combination of in vitro and in vivo approaches we dissect the functions of CBP and P300 in different steps of neural development. We first demonstrate in vitro that proliferation of neural progenitors is not affected in the absence of CBP or P300 but is seriously compromised when both proteins are absent simultaneuosly. In addition, elimination of either CBP or P300 impedes neuronal and glial differentiation although they are not individually required to preserve neuronal identity. Removal of CBP, p300 or both in retinal progenitors or postmitotic retinal ganglion cells confirm these results in vivo and demonstrate that CBP plays a more prominent role than P300 during retinal differentiation. These data contribute to a better understanding on the individual roles of KAT3 proteins in neural differentiation and may help on the prevention and treatment of RSTS patients.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent198es_ES
dc.language.isoenges_ES
dc.publisherUniversidad Miguel Hernández de Elchees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeurobiologíaes_ES
dc.subjectBiología moleculares_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nerviosoes_ES
dc.titleThe role of KAT3 proteins in neural developmentes_ES
dc.typeinfo:eu-repo/semantics/doctoralThesises_ES
dc.contributor.instituteInstitutos de la UMH::Instituto de Neurocienciases_ES
Appears in Collections:
Tesis doctorales - Ciencias de la Salud


Thumbnail

View/Open:
 Tesis Rocio Gonzalez Martinez_2_compressed.pdf
2,33 MB
Adobe PDF
Share:


Creative Commons ???jsp.display-item.text9???