Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/29196
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dc.contributor.authorGehrke, Sergio-
dc.contributor.authorAramburú Junior, Jaime-
dc.contributor.authorEliers Treichel, Tiago Luis-
dc.contributor.authorRodriguez, Fernando-
dc.contributor.authorDe Aza, Piedad-
dc.contributor.authorDedavid, Berenice Anina-
dc.contributor.otherDepartamentos de la UMH::Ciencia de Materiales, Óptica y Tecnología Electrónicaes_ES
dc.date.accessioned2023-04-25T11:31:39Z-
dc.date.available2023-04-25T11:31:39Z-
dc.date.created2022-07-
dc.identifier.citationJournal of Applied Biomaterials & Functional Materials 1–13 (2022)es_ES
dc.identifier.issn2280-8000-
dc.identifier.urihttps://hdl.handle.net/11000/29196-
dc.description.abstractA large number of materials with different compositions and shapes have been proposed and studied for the purpose of bone tissue regeneration. Collagen-based materials have shown promising results for this application, with improved physicochemical properties. The aim of the present in vivo animal study was to evaluate and compare two commercially available collagen-based biomaterials for bone regeneration, with these being implanted in circumferential bone defects created in the calvarium of rabbits. Twenty rabbits received bilateral parietal osteotomies, performed with the aid of a 6.5 mm diameter trephine. Two groups were created: the BC group, where the defect was filled with a scaffold composed of 90% bovine bone particles and 10% porcine collagen, and the EG group, where the defect was filled with a scaffold composed of 75% hydroxyapatite particles of bovine origin and 25% bovine collagen. Ten animals were sacrificed at 30 days and another 10 at 45 days after implantation, and the samples were processed and histologically analyzed. In the evaluations of the samples at 30 days, no important differences were found in the results. However, in the samples at 45 days after surgery, the EG group showed better results than the BC group samples, mainly in terms of the amount of bone matrix formation (P < 0.0001) and the volume in area measured in each sample, where the EG group had a value 65% higher than that in the BC group samples. Based on the results obtained, we conclude that the amount of collagen and the particle characteristics present in the composition of the scaffolds can directly influence the amount of neoformation and/or bone regeneration.es_ES
dc.description.sponsorshipThis study was funded by MCIN/AEI10.13039/501100011033, Grant PID2020-116693RB-C21.-
dc.formatapplication/pdfes_ES
dc.format.extent13es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnimal studyes_ES
dc.subjectbone defectes_ES
dc.subjectbone ingrowthes_ES
dc.subjectbone regenerationes_ES
dc.subjectcollagen-based biomaterialses_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::62 - Ingeniería. Tecnologíaes_ES
dc.titleComparative evaluation of two collagenbased biomaterials with different compositions used for bone graft: An experimental animal studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1177/22808000221119650es_ES
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