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dc.contributor.authorMata, Nayarit A-
dc.contributor.authorArango-Ospinab, Marcela-
dc.contributor.authorVelasquez, Pablo-
dc.contributor.authorMurciano, Ángel-
dc.contributor.authorde Haza, Piedad N.-
dc.contributor.authorBoccaccini, Aldo R.-
dc.contributor.otherDepartamentos de la UMH::Biología Aplicadaes_ES
dc.date.accessioned2022-07-28T07:13:39Z-
dc.date.available2022-07-28T07:13:39Z-
dc.date.created2021-11-15-
dc.identifier.citationBoletín de la Sociedad Española de Cerámica y Vidrio Available online 1 December 2021es_ES
dc.identifier.urihttps://hdl.handle.net/11000/27575-
dc.description.abstractIn this work, a new combination of ceramic materials is proposed for bone tissue engi neering applications. Multilayer scaffolds consisting of a core composed mainly of calcium pyrophosphate and external coatings of silica and calcium doped with Fe3+, Sr2+ and Mg2+ were prepared. To study the influence of the arrangement of dopant ions in the external coatings, two different scaffolds were developed: scaffolds 3J consisting of a single exter nal coating with 9mol% of Fe3+, Sr2+ and Mg2+ ions; and scaffolds 3S comprising three external coatings, each containing 3mol% of Fe3+, Sr2+ and Mg2+ ions. Scaffolds were physico chemically characterized and evaluated for in vitro bioactivity and cellular response in the presence of MG-63 cells. The results showed that the core scaffold displayed no in vitro bioac tivity or good cellular response, but served as a support for the external coatings given its mechanical resistance. The cell viability of scaffolds 3J and 3S increased more than 100% in relation to the core, and also improved cell proliferation and adhesion resulting in a dense layer of cells that covered the scaffolds’ entire surface. The arrangement of ions in the external coatings did not influence the cellular response, but determined the bioactivity ratees_ES
dc.description.sponsorshipNayarit A. Mata was funded by a grant from the Generalitat Valenciana with reference GRISOLIAP/2018/037 and pre-doctoral mobility co-financed by the European Social Fund and the Generalitat Valenciana with reference BEFPI/2021/056. T-
dc.description.sponsorshipThis publication is part of the Grant PID2020- 116693RB-C21 funded by MCIN/AEI/10.13039/501100011033.-
dc.formatapplication/pdfes_ES
dc.format.extent15es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBioceramicses_ES
dc.subjectSol–geles_ES
dc.subjectScaffoldses_ES
dc.subjectIon dopinges_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::62 - Ingeniería. Tecnologíaes_ES
dc.titleEffect of Sr, Mg and Fe substitution on the physico-chemical and biological properties of Si Ca P multilayer scaffoldses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.contributor.instituteInstitutos de la UMH::Instituto de Bioingenieríaes_ES
dc.identifier.doi10.1016/j.bsecv.2021.11.005-
dc.relation.publisherversionhttps://doi.org/10.1016/j.bsecv.2021.11.005-
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Instituto de Bioingeniería


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