Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/1794

The morphogenetic role wnt1 in the diencephalic regionalization


Thumbnail

View/Open:
 Maria Navarro Garberi.pdf
4,82 MB
Adobe PDF
Share:
Title:
The morphogenetic role wnt1 in the diencephalic regionalization
Authors:
Navarro Garberí, María
Tutor:
Martínez Pérez, Salvador
Geijo Barrientos, Emilio
Department:
Instituto de Neurociencias
Issue Date:
2014-07-23
Abstract:
The diencephalon is a complex brain area which derives from the caudal region of the prosencephalon. This structure is divided in horizontal zones along the dorso-ventral axis. The mechanisms that govern the formation of this axis during development remain unclear. Different signaling molecules have been described as involved in this process, known as morphogenes, which induce a specific neural fate to the neighbouring epithelium. In order to demonstrate that one of these signaling molecules, Wnt1, has a critical role in the correct establishment of the diencephalic territories, we carried out gain- and loss-of-function experiments. Our results indicate that Wnt1 signal has a key role in the structuration of the pretectal territories during embryonic development, as well as in the correct development of some diencephalic dorsal structures. Moreover, we demonstrate that Wnt1 signal is required for the diencephalic dorso-ventral regionalization. We further show that Wnt1 is directly induced by Bmp4, unraveling the molecular regulatory code modulating this regionalization in the diencephalon.
Keywords/Subjects:
Neurociencias
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
Appears in Collections:
Tesis doctorales - Ciencias de la Salud



Creative Commons ???jsp.display-item.text9???