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Human mesenchymalstemcellviability,proliferationanddifferentiation potential inresponsetoceramicchemistryandsurfaceroughness


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Title:
Human mesenchymalstemcellviability,proliferationanddifferentiation potential inresponsetoceramicchemistryandsurfaceroughness
Authors:
De Aza Moya, Piedad N.
Mazón, Patricia
García-Bernal, David
Meseguer-Olmo, Luis
Cragnolini, Francesca
Department:
Departamentos de la UMH::Ciencia de Materiales, Óptica y Tecnología Electrónica
Issue Date:
2015-01
Abstract:
We investigatedtheeffectoftheceramicchemistryandsurfaceroughnessofpure α-tricalcium phosphate,andalso αTCP dopedwitheither 1.5 wt%or3.0wt%ofdicalciumsilicate(C2S), ontheresponseofadulthumanmesenchymalstemcells(ahMSCs). AhMSCs wereplatedonto ceramic discs,preparedbyasolid-statereaction.Afterbeingsintered,somesampleswerepolishedupto1 μm, whileotherswerekeptas manufactured, whichresultedintwosurfaceroughnessgrades.Viability,proliferationandosteoinductivecapacityweredeterminedfollowing various incubationperiods. The resultsshowedanon-cytotoxiceffectafteranindirectapoptosistest.Celladhesionandproliferationweresurfaceroughness-sensitiveand increased proportionallytotheroughnessofmaterials.Theseobservationsbecamemoreevidentintheunpolished αTCP ceramicdopedwith 1.5 wt%C2S, whichinducedosteoblasticdifferentiationasaresultoftheroughnessandincreasedconcentrationoftheC2S solidsolution in αTCP.
Keywords/Subjects:
biomateriales
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
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